Study on Adequacy of Sample for Histopathology of Intracranial Lesions Taken from Frame Based and Frameless Navigation Guided Biopsy

Authors

  • Sushil Mohan Bhattarai National Academy of Medical Sciences
  • Namrata Khadka National Academy of Medical Sciences
  • Prabhat Jha National Academy of Medical Sciences
  • Pratibha Bista National Academy of Medical Sciences
  • Rajiv Jha National Academy of Medical Sciences
  • Prakash Bista National Academy of Medical Sciences

Keywords:

Adequacy, Frameless, Framebased, neuronavigation, Histopathology

Abstract

Introduction: Neuronavigation guided biopsy (Frameless and Framebased stereotactic) is a simplified procedure which helps the neurosurgeons to precisely obtain the biopsy of intracranial lesions to establish the complex histopathological diagnosis.These procedures are commonly performed at our centre. The small tissue sample acquired when viewed against the vast heterogenicity of lesions and the rapidly progressive nature of few tumours make the adequacy of sample, an important parameter in determining the effectiveness of the procedure, which also has profound financial and disease related impact on the patients’ life. The objective of this study was to determine the rate of adequate sample for histopathological examination from intracranial lesions.

 

Methods: A prospective observational study was done in 49 patients who underwent frameless and framebased biopsies at National Neurological Referral Centre,Bir Hospital in one year.

 

Results: A total of  36 (73.5%) patients underwent frameless biopsy and 13(23.5%) patients underwent frame based stereotactic biopsy of intracranial lesions.Overall diagnostic yield was 89.8% with Frameless procedure giving histopathological diagnostic yield of 91.66% and framebased procedure had diagnostic yield of 84.61%.Hematoma occurred in 2 patients and seizure occurred in one patient. Majority of histopathological diagnosis was Glioblastoma(44.9%).

 

Conclusion: Neuronavigation guided biopsy sample of intracranial lesions obtained for histopathological diagnosis is adequate in establishing the final histopathological diagnosis which helps in enhancing patient management and outcome.

Author Biographies

Namrata Khadka, National Academy of Medical Sciences

Lecturer, Department of Neurosurgery

Prabhat Jha, National Academy of Medical Sciences

Senior Resident, Neurosurgery, NAMS

Pratibha Bista, National Academy of Medical Sciences

Professor, Department of Pathology, NAMS

Rajiv Jha, National Academy of Medical Sciences

Professor, Department of Neurosurgery, NAMS

Prakash Bista, National Academy of Medical Sciences

Professor and Head, Department of Neurosurgery, NAMS

References

Tubbs RS, Hill M, Loukas M, Shoja MM, Oakes WJ. Volumetric analysis of the posterior cranial fossa in a family with four generations of the Chiari malformation Type I. J Neurosurg Pediatr. 2008;1(1):21-4. https://doi.org/10.3171/ped-08/01/021

Nair DR, Burgess R, McIntyre CC, Lüders H. Chronic subdural electrodes in the management of epilepsy. Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology. 2008;119(1):11-28. https://doi.org/10.3171/ped-08/01/021

Apuzzo ML, Chandrasoma PT, Cohen D, Zee CS, Zelman V. Computed imaging stereotaxy: experience and perspective related to 500 procedures applied to brain masses. Neurosurgery. 1987;20(6):930-7.https://doi.org/10.1227/00006123-198706000-00019. PMID: 3302751.

Laitinen LV. My 50 years of interest in stereotactic and functional neurosurgery. Stereotact Funct Neurosurg. 2001;77(1-4):7-10. doi: 10.1159/000064586. PMID: 12378048.

Johnson RD, Stacey RJ. The impact of new imaging technologies in neurosurgery. Surgeon. 2008;6(6):344-9. https://doi.org/10.1016/s1479-666x(08)80006-6

Woodworth G, McGirt MJ, Samdani A, Garonzik I, Olivi A, Weingart JD. Accuracy of frameless and frame-based image-guided stereotactic brain biopsy in the diagnosis of glioma: comparison of biopsy and open resection specimen. Neurol Res. 2005;27(4):358-62. doi: 10.1179/016164105X40057. PMID: 15949232.

Woodworth GF, McGirt MJ, Samdani A, et al. Frameless image guided stereotactic brain biopsy procedure: diagnostic yield, surgical morbidity, and comparison with the frame-based technique. J Neurosurg. 2006;104:233-237. doi.org/10.3171/jns.2006.104.2.233

Quiñones-Hinojosa A, Ware ML, Sanai N, McDermott MW. Assessment of image guided accuracy in a skull model: comparison of frameless stereotaxy techniques vs. frame-based localization. J Neurooncol. 2006;76(1):65-70. doi: 10.1007/s11060-005-2915-z. PMID: 16132501.

Kongkham PN, Knifed E, Tamber MS, Bernstein M. Complications in 622 cases of frame-based stereotactic biopsy, a decreasing procedure. Can J Neurol Sci. 2008;35(1):79-84. doi: 10.1017/s0317167100007605. PMID: 18380282.

Gerard IJ, Kersten-Oertel M, Petrecca K, Sirhan D, Hall JA, Collins DL. Brain shift in neuronavigation of brain tumors: A review. Med Image Anal. 2017;35:403-420. doi: 10.1016/j.media.2016.08.007. Epub 2016 Aug 24. PMID: 27585837.

Jha R, Khambu B, Shrestha R, Bista P. Neuronavigation system in neurosurgery: Technical details and our early clinical experiences. Nepal Journal of Neuroscience. 2021;18(1); 45-50. https://doi.org/10.3126/njn.v18i1.35017

Thulung S, Bishokarma S, Lohani S, Shrestha D, Aryal B, Napit M. Clinical Experience With Frameless Neuronavigation Guided Biopsy For Intracranial Space Occupying Lesion. Nepal Journal of Neuroscience. 2019; 12;16(1):25-8. https://doi.org/10.3126/njn.v16i1.24427

Kesserwan MA, Shakil H, Lannon M, McGinn R, Banfield L, Nath S, Alotaibi M, Kasper E, Sharma S. Frame-based versus frameless stereotactic brain biopsies: A systematic review and meta-analysis. Surg Neurol Int. 2021 Feb 10;12:52. https://doi.org/10.25259%2FSNI_824_2020/SNI_824_2020. PMID: 33654555; PMCID: PMC7911151.

Jain D, Sharma MC, Sarkar C, Gupta D, Singh M, Mahapatra A K. Comparative analysis of diagnostic accuracy of different brain biopsy procedures. Neurol India [serial online] 2006 DOI: 10.4103/0028-3886.28113

Ordóñez-Rubiano EG, Rodríguez-Vargas S, Ospina-Osorio J, Zorro-Guío OF, Patiño JG, Sánchez Rueda M. Stereotactic frame-based guided brain biopsies: experience in a center in Latin America. Rev. Chil. Neurocirugía 44: 140-144, 2018

Pennlund A, Jakola AS, Skoglund T, Ljungqvist J. A single-centre study of frame-based stereotactic brain biopsies. British Journal of Neurosurgery. 2022 Mar 4;36(2):213-6. https://doi.org/10.1080/02688697.2020.1867704

Dammers R, Haitsma IK, Schouten JW, Kros JM, Avezaat CJ, Vincent AJ. Safety and efficacy of frameless and frame-based intracranial biopsy techniques. Acta neurochirurgica. 2008;150:23–29. [PubMed] [Google Scholar]

Dorward NL, Paleologos TS, Alberti O, Thomas DG. The advantages of frameless stereotactic biopsy over frame-based biopsy. British journal of neurosurgery. 2002;16:110–118. [PubMed] [Google Scholar]

Smith JS, Quinones-Hinojosa A, Barbaro NM, McDermott MW. Frame-based stereotactic biopsy remains an important diagnostic tool with distinct advantages over frameless stereotactic biopsy. Journal of neuro-oncology. 2005;73:173–179. [PubMed] [Google Scholar]

Woodworth GF, McGirt MJ, Samdani A, Garonzik I, Olivi A, Weingart JD. Frameless image-guided stereotactic brain biopsy procedure: diagnostic yield, surgical morbidity, and comparison with the frame-based technique. Journal of neurosurgery. 2006;104:233–237. [PubMed] [Google Scholar]

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Published

2022-08-31

How to Cite

1.
Bhattarai SM, Khadka N, Jha P, Bista P, Jha R, Bista P. Study on Adequacy of Sample for Histopathology of Intracranial Lesions Taken from Frame Based and Frameless Navigation Guided Biopsy . Journal of Karnali Academy of Health Sciences [Internet]. 2022Aug.31 [cited 2024May17];5(2). Available from: http://jkahs.org.np/jkahs/index.php/jkahs/article/view/594

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Vol. 5 No. 2 (2022): JKAHS; May-Aug Issue (14)

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Original Article

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Copyright (c) 2022 Sushil Mohan Bhattarai, Namrata Khadka, Prabhat Jha, Pratibha Bista, Rajiv Jha, Prakash Bista

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