Bacterial Pathogens responsible for Urinary Tract Infection among Patients Attending a Tertiary Hospital in Eastern Nepal

Authors

  • Tula Krishna Gupta KAHS, JUMLA
  • Bishnu Timilsina
  • Bijendra Kumar Rai BP Koirala Institute of Health Sciences, Dharan, Nepal
  • Ajay Kumar Yadav B.P.Koirala Institute of Health Sciences, Dharan Nepal
  • Ratna Baral BP Koirala Institute of Health Sciences, Dharan, Nepal
  • Smriti Mayur Kasaudhan Epidemiology and Disease Control Division

Keywords:

Urinary tract infection (UTI), , Bacterial pathogen, Antibiotics, Antibiotic susceptibility

Abstract

Introduction: UTI has been more complicated to treat because of the appearance of the pathogen with increasing resistance to antimicrobial agents. It is useful to obtain the local sensitivity pattern in the hospital setting to guide empirical prescription.

Methods: This is a prospective hospital-based study to identify the organisms causing UTI and their antibiotic susceptibility. A total of 400 urine samples were collected from the patients attending general OPD of BPKIHS, Dharan, Nepal, having the symptoms of UTI using the purposive sampling technique. We analyzed the midstream, clean catch of the urine and cultured to analyze the bacterial presence. Antibiotics susceptibility was tested using the Kirby-Bauer Disk Diffusion method. The findings were analyzed for the presence of bacteria in different age and sex groups along with their response to different antibiotics commonly used in Nepal.

Results: Out of 400 culture samples, 163 (40.7%) showed bacterial growth. Escherichia coli was the most common bacteria (68.7%), followed by Klebsiella spp. (7.4%). Female urine samples showed more bacterial growth compared to males (2.79:1). UTI was common among the young population of the age group (20-29 years). Most of the isolated bacteria were sensitive to Nitrofurantoin (89.7%).

Conclusion: UTI commonly occurs both in males and males of all age groups. However, females are more vulnerable to infection. Among many, E. coli is the most prevalent pathogen causing the disease, which is more susceptible to nitrofurantoin. Similarly, this antibiotic is sensitive to the majority of bacteria. Therefore, nitrofurantoin may be the first choice of drug for the population in the Eastern part of Nepal suffering from UTI. Since this study was carried out among a small sample size in one tertiary care hospital, we recommend a bigger study covering a larger population, to further validate the result.

Author Biography

Tula Krishna Gupta, KAHS, JUMLA

Tula Krishna Gupta was born in the Saptary district of Nepal. He did his post-graduation in General Practice and Emergency Medicine in 2016 from B. P. Koirala Institute of Health Sciences, Dharan, Nepal. He is currently working in the rural part of Nepal as assistant professor in Karnali Academy of Health Science, Jumla. Besides playing a leading role in the Medical team, his responsibilities include providing direct care to the patients, medical services management, and quality improvement. He wants to advocate for health systems and patients in the future. His hobbies include travel and learning from different cultures.

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Published

2022-04-30

How to Cite

1.
Gupta T, Timilsina B, Rai B, Yadav A, Baral R, Kasaudhan S. Bacterial Pathogens responsible for Urinary Tract Infection among Patients Attending a Tertiary Hospital in Eastern Nepal. Journal of Karnali Academy of Health Sciences [Internet]. 2022Apr.30 [cited 2024May9];5(1). Available from: https://jkahs.org.np/jkahs/index.php/jkahs/article/view/390

Issue

Vol. 5 No. 1 (2022): JKAHS; Jan-Apr Issue (13)

Section

Original Article

License

Copyright (c) 2022 Dr. Tula Krishna Gupta, Dr. Bijendra Kumar Rai, Dr. Ajay Kumar Yadav, Dr. Ratna Baral, Dr. Smriti Mayur Kasaudhan, Bishnu Timilsina

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