Effect of Magnesium Sulphate with Bupivacaine in Ultrasound-guided Transversus Abdominis Plane Block in patients undergoing Total Abdominal Hysterectomy
Keywords:
Bupivacaine, Magnesium sulphate, Postoperative analgesia, TAP blockAbstract
Background: Transversus abdominis plane block is a valuable component of multimodal analgesia regimen. Magnesium sulphate has been shown to increase the duration of action of different peripheral nerve blocks. We assessed the efficacy of magnesium sulphate as an adjuvant to bupivacaine in transversus abdominis plane block in patients scheduled for total abdominal hysterectomy under general anaesthesia.
Methods: Sixty-six patients undergoing total abdominal hysterectomy under general anaesthesia were divided into two groups. Ultrasound-guided bilateral transversus abdominis plane block was performed in both groups before extubation. Bupivacaine alone group received block with 20ml of 0.25% bupivacaine while Bupivacaine with Magnesium group received block with 20ml of 0.25% bupivacaine with 150mg of magnesium sulphate on each side. Pain scores at 0, 2, 4, 6, 12, and 24 hours postoperatively along with time to first request of analgesia, total consumption of fentanyl, and incidence of nausea or vomiting were noted.
Results: Group BM showed significantly lower pain scores at 4 and 6 hours (p=0.001 and 0.017 respectively). Time to first request of analgesia was significantly more in Group BM [285 minutes (85, 370) vs. 75 minutes (52.5, 150), (p<0.001)]. Total postoperative fentanyl consumption was significantly less in Group BM (230±59.06 mcg vs. 289.85±69.13 mcg, p<0.001).
Conclusions: Bupivacaine with magnesium sulphate in transversus abdominis plane block after total abdominal hysterectomy under general anaesthesia results in lower post-operative pain scores, longer duration of analgesia and less postoperative fentanyl requirement with no difference in the incidence of nausea/vomiting compared with bupivacaine alone.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2021 Authors
This work is licensed under a Creative Commons Attribution 4.0 International License.
The author(s) retain the copyright and the full publishing right without restriction under the Creative Commons Attribution 4.0 International License (CC BY 4.0) which allows readers to share (copy and redistribute the material in any medium or format) and adapt (remix, transform, and build upon the material) for any purpose, even commercially, provided the work is properly attributed. (https://creativecommons.org/licenses/by/4.0/).
Author(s) grant the non-exclusive publishing right to the Journal of Karnali Academy of Health Sciences (JKAHS). The publishing rights include the rights to publish, reproduce, distribute, include in indexes or search databases or other media in print or online. The JKAHS may require revisions to the manuscript before acceptance for publication or may choose not to publish it based on the judgement of the editors. Further, JKAHS might retract, withdraw, or publish a correction or other notice after publication, if such publication would be inconsistent with the good publication practices and associated guidelines set forth by the COPE (Committee on Publication Ethics) (https://publicationethics.org/core-practices).
More information about the Creative Commons Attribution 4.0 International License can be found in the webpage of Creative Commons (CC) by following the link provided below: https://creativecommons.org/licenses/by/4.0/