Rationale of α-Ketoanalogue Supplemented with Low Protein Diet for the Treatment of Chronic Kidney Disease
Keywords:
Protein-Restricted Diet, Creatinine, Sodium, Potassium, Serum Albumin, Chronic Renal InsufficiencyAbstract
Background: Chronic kidney disease (CKD) has challenged the healthcare system for years. Use of α-ketoanalogue (KA) supplemented with a low protein diet (LPD) may improve renal function. In this study, we aim to find out the effectiveness of KA supplemented with LPD for the therapy of CKD.
Methods: A descriptive cross-sectional study was conducted at Shree Birendra Hospital with 25 control and 25 treatment group. The control group was treated with LPD (0.8 g/kg/day), while the test group was treated with KA (3 tablets/day for 4 weeks followed by 6 tablets/day for the next 16 weeks) along with LPD. The baseline parameters were measured on day 0, then subsequently at week 4, week 12, and lastly at the end of week 16. Results were then compared with the control group for analysis.
Results: Serum level of creatinine showed a progressive decline in the treatment group in comparison to the control group. However, there was a progressive decline in the level of blood urea in the first 4 weeks (84.33) and 12 weeks (72.11) of treatment, a slight increment was observed in week 16 (86.06) but the level was below the baseline value. Similarly, the blood level of sodium and potassium was slightly affected by the increase in sodium and decrease in potassium level from the baseline in the treatment group. The level of serum albumin was increased in the treatment group as compared to the control group. The systolic blood pressure was increased in both treatment and control group whereas diastolic blood pressure was decreased in the treatment group rather than the control group.
Conclusion: KA supplemented with LPD shows a significant improvement in renal function of CKD III patients that delay the time for dialysis or transplant. However, further substantial multi-institutional randomized studies are necessary to generalize the findings.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2020 Sitaram Khadka, Arun Sharma, Kapil Amgain, Smriti, Prem
This work is licensed under a Creative Commons Attribution 4.0 International License.
The author(s) retain the copyright and the full publishing right without restriction under the Creative Commons Attribution 4.0 International License (CC BY 4.0) which allows readers to share (copy and redistribute the material in any medium or format) and adapt (remix, transform, and build upon the material) for any purpose, even commercially, provided the work is properly attributed. (https://creativecommons.org/licenses/by/4.0/).
Author(s) grant the non-exclusive publishing right to the Journal of Karnali Academy of Health Sciences (JKAHS). The publishing rights include the rights to publish, reproduce, distribute, include in indexes or search databases or other media in print or online. The JKAHS may require revisions to the manuscript before acceptance for publication or may choose not to publish it based on the judgement of the editors. Further, JKAHS might retract, withdraw, or publish a correction or other notice after publication, if such publication would be inconsistent with the good publication practices and associated guidelines set forth by the COPE (Committee on Publication Ethics) (https://publicationethics.org/core-practices).
More information about the Creative Commons Attribution 4.0 International License can be found in the webpage of Creative Commons (CC) by following the link provided below: https://creativecommons.org/licenses/by/4.0/
